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Synthetic Approaches to Spiroaminals
Author(s) -
Sinibaldi MarieEve,
Canet Isabelle
Publication year - 2008
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200800371
Subject(s) - nonane , undecane , chemistry , decane , novelty , ring (chemistry) , organic chemistry , stereochemistry , theology , philosophy
The 1‐oxa‐7‐azaspiro[5.5]undecane, 1‐oxa‐6‐azaspiro[4.5]decane, 1‐oxa‐7‐azaspiro[5.4]decane and 1‐oxa‐6‐azaspiro[4.4]nonane ring systems are found as the cores of natural or synthetic products that possess significant biological activities. Because of their potential applications, together with the novelty of their skeletons, these compounds represent challenging targets for chemical synthesis. In this review we summarize the different strategies developed for the synthesis of these spiroaminals.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)