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Copper Zeolites as Green Catalysts for Multicomponent Reactions of Aldehydes, Terminal Alkynes and Amines: An Efficient and Green Synthesis of Propargylamines
Author(s) -
Patil Meghshyam K.,
Keller Murielle,
Reddy Benjaram M.,
Pale Patrick,
Sommer Jean
Publication year - 2008
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200800359
Subject(s) - chemistry , catalysis , solvent , copper , organic chemistry , heterogeneous catalysis , aldehyde , terminal (telecommunication) , combinatorial chemistry , telecommunications , computer science
Cu I ‐modified zeolites, especially Cu I ‐USY, have proved to be very efficient catalysts in multicomponent reactions, allowing for a solvent‐free synthesis of propargylamines from aldehydes, amines, and terminal alkynes. With a heterogeneous catalyst and in the absence of solvent, this process is among the greenest ever reported. A mechanism has been proposed for this three‐component reaction.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)