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Functionalization of Tripodal Scaffold Molecules on Solid Support
Author(s) -
Guarise Cristian,
Zaupa Giovanni,
Prins Leonard J.,
Scrimin Paolo
Publication year - 2008
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200800259
Subject(s) - chemistry , scaffold , surface modification , molecule , intramolecular force , combinatorial chemistry , solid phase synthesis , nanotechnology , stereochemistry , organic chemistry , biochemistry , medicine , peptide , materials science , biomedical engineering
A versatile synthetic approach is described for the functionalization of tripodal scaffold molecules on solid support. Intrinsic problems related to the attachment of tripodal scaffolds to a resin (for example mono‐ vs. polyadducts and intramolecular cyclizations) are studied and solutions are provided. The synthetic approach relies on the use of specific protecting groups in the critical steps of the synthesis. Importantly, however, protecting groups on the scaffold molecule are never used, which significantly facilitates scaffold variation, for instance in combinatorial studies. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)