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Dynamic Kinetic Resolution of α‐Amino Acid Esters in the Presence of Aldehydes
Author(s) -
Schichl Daniel A.,
Enthaler Stephan,
Holla Wolfgang,
Riermeier Thomas,
Kragl Udo,
Beller Matthias
Publication year - 2008
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200800253
Subject(s) - racemization , chemistry , kinetic resolution , hydrolysis , yield (engineering) , catalysis , lipase , organic chemistry , amino acid , resolution (logic) , enzyme , enantioselective synthesis , biochemistry , materials science , artificial intelligence , computer science , metallurgy
A convenient procedure for the racemization of α‐amino acid esters in the presence of catalytic amounts of salicylaldehydes is described. The combination of this racemization protocol with lipase‐catalyzed ester hydrolysis allows successful dynamic kinetic resolution of various α‐amino acid esters. The corresponding α‐amino acids are obtained in high yield and optical purity.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)