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Synthesis of Natural Product Derivatives Containing 2,4‐Concatenated Oxazoles
Author(s) -
Hernández Delia,
Riego Estela,
Albericio Fernando,
Álvarez Mercedes
Publication year - 2008
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200800111
Subject(s) - oxazole , chemistry , ring (chemistry) , natural product , amide , combinatorial chemistry , peptide bond , stereochemistry , peptide , organic chemistry , biochemistry
Herein is described the synthesis of several oxazole‐containing derivatives of IB‐01211. The macrocyclization reaction of peptide 14 containing a concatenated triazole was successful and afforded 3 by amide bond formation. However, for those compounds containing quaterazoles or quinqueazoles, the oxazole ring had to be formed during macrocyclization. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)