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Bis(diamido)‐Bridged Basket Resorcin[4]arenes as Enantioselective Receptors for Amino Acids and Amines (Eur. J. Org. Chem. 36/2007)
Author(s) -
Botta Bruno,
D'Acquarica Ilaria,
Nevola Laura,
Sacco Fabiola,
Lopez Zara Valbuena,
Zappia Giovanni,
Fraschetti Caterina,
Speranza Maurizio,
Tafi Andrea,
Caporuscio Fabiana,
Letzel Matthias C.,
Mattay Jochen
Publication year - 2007
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200790097
Subject(s) - chemistry , enantioselective synthesis , enantiomer , molecule , calixarene , chloroform , stereochemistry , crystallography , organic chemistry , catalysis
The cover picture shows two low‐energy geometries of a new bis(diamido)‐bridged basket resorcin[4]arene, which features two (1 R ,2 R )‐(+)‐1,2‐diphenylethylenediamine bridges in its structure. The first “drops” schematically show the geometry assumed by the molecule in chloroform solution, tentatively designated as the “folded wings” structure (bottom left); the top right structure represents the geometry adopted when the solvent is removed and is named the “open wings” structure. Stochastic dynamics simulations run at 300 K, which demonstrate the irreversible conversion of the latter structure into the former one, support the “folded wings” geometry as the most likely 3D structure of the basket resorcin[4]arene in chloroform. It can be shown by FT‐ICR mass spectrometry that such a receptor can selectively accommodate the enantiomers of amino acid derivatives and amphetamine in its chiral cavity. Details are discussed in the article by B. Botta, M. Speranza et al. on p. 5995 ff. The authors thank Dr. Giovanna Cancelliere and Dr. Deborah Subissati for their contribution in designing the cover page.