Premium
Cover Picture: Acetylene‐Substituted Phosphane Oxides: Building Blocks for Macrocycles (Eur. J. Org. Chem. 15/2007)
Author(s) -
van Assema Sander G. A.,
de Jong G. Bas,
Ehlers Andreas W.,
de Kanter Frans J. J.,
Schakel Marius,
Spek Anthony L.,
Lutz Martin,
Lammertsma Koop
Publication year - 2007
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200790028
Subject(s) - chemistry , acetylene , benzene , amide , oxidative coupling of methane , combinatorial chemistry , medicinal chemistry , stereochemistry , organic chemistry , methane
The cover picture shows the synthesis of three novel phosphorus‐based macrocycles with acetylenic scaffolds from simple and accessible building blocks. The 14‐membered macrocycle was obtained as cis and trans isomers from cyclization of diisopropylphosphoramidic dibromide and 1,2‐bis(ethynyl)benzene. The four‐ and six‐edged macrocycles in which the i Pr 2 NP(O) units are connected through 1,3‐butadiyne rods were obtained after multiple acetylene coupling reactions under oxidative Hay conditions starting from the diethynylphosphinic amide building block. Further details are discussed in the article by K. Lammertsma et al. on p 2405 ff.