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A Convenient Synthesis of Cyanine Dyes: Reagents for the Labeling of Biomolecules
Author(s) -
Kvach Maksim V.,
Ustinov Alexey V.,
Stepanova Irina A.,
Malakhov Andrei D.,
Skorobogatyi Mikhail V.,
Shmanai Vadim V.,
Korshun Vladimir A.
Publication year - 2008
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200701190
Subject(s) - chemistry , reagent , cyanine , phosphoramidite , biomolecule , oligonucleotide , combinatorial chemistry , organic chemistry , fluorescence , biochemistry , dna , physics , quantum mechanics
Four tetramethylindo(di)carbocyanine‐derived carboxylicacids have been prepared using a modified one‐pot procedure for the dye assembly. The acids were converted into oxysuccinimide esters and phosphoramidite reagents. The efficiency of the reagents in the labeling of oligonucleotides and proteins has been demonstrated. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)