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A Novel Chiral (salen)Al III Complex Catalyzed Asymmetric Cyanosilylation of Aldehydes
Author(s) -
Zeng Zebing,
Zhao Guofeng,
Zhou Zhenghong,
Tang Chuchi
Publication year - 2008
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200701161
Subject(s) - chemistry , catalysis , metal salen complexes , enantioselective synthesis , organic chemistry , combinatorial chemistry , polymer chemistry , medicinal chemistry
A novel chiral (salen)Al III complex was synthesized through the reaction of Et 2 AlCl and salen ( R , R )‐ 1 derived from ( R , R )‐11,12‐diamino‐9,10‐dihydro‐9,10‐ethanoanthracene. This complex is an efficient catalyst for the asymmetric trimethylsilylcyanation of aldehydes in the presence of tributylphosphane oxide as an additive. The use of 1 mol‐% of the complex led to the corresponding cyanohydrins in high yields (85–94 %) with good‐to‐excellent enantioselectivities (42–92 % ee ).(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)