Chiral Phosphoric Acid Catalyzed Asymmetric Friedel–Crafts Alkylation of Indoles with Simple α,β‐Unsaturated Aromatic Ketones | Zendy

Tang HongYing | Zendy; Lu AiDang | Zendy; Zhou ZhengHong | Zendy; Zhao GuoFeng | Zendy; He LianNian | Zendy; Tang ChuChi | Zendy

Premium

Chiral Phosphoric Acid Catalyzed Asymmetric Friedel–Crafts Alkylation of Indoles with Simple α,β‐Unsaturated Aromatic Ketones

Author(s) -

Tang HongYing,

Lu AiDang,

Zhou ZhengHong,

Zhao GuoFeng,

He LianNian,

Tang ChuChi

Publication year - 2008

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.200700980

Subject(s) - friedel–crafts reaction , chemistry , phosphoric acid , alkylation , catalysis , organic chemistry , medicinal chemistry

Asymmetric Michael‐type Friedel–Crafts (F‐C) alkylations of indoles with nonchelating α,β‐unsaturated aromatic ketones catalyzed by a chiral H 8 ‐BINOL‐based phosphoric acid were investigated. The reactions took place smoothly in the presence of only 2 mol‐% of catalyst at room temperature to afford the desired F‐C alkylation products in good yields and with moderate enantioselectivities.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research