Synthesis and Biological Evaluation of Methylene‐Bridged Analogs of the Potent Cannabinoid Receptor Antagonist Rimonabant | Zendy

Ślusarczyk Magdalena | Zendy; De Borggraeve Wim M. | Zendy; Hoornaert Georges | Zendy; Deroose Frederik | Zendy; Linders Joannes T. M. | Zendy

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Synthesis and Biological Evaluation of Methylene‐Bridged Analogs of the Potent Cannabinoid Receptor Antagonist Rimonabant

Author(s) -

Ślusarczyk Magdalena,

De Borggraeve Wim M.,

Hoornaert Georges,

Deroose Frederik,

Linders Joannes T. M.

Publication year - 2008

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.200700960

Subject(s) - rimonabant , chemistry , cannabinoid receptor , methylene , antagonist , cannabinoid , pyrazine , cannabinoid receptor antagonist , derivative (finance) , stereochemistry , receptor , pharmacology , medicinal chemistry , biochemistry , medicine , financial economics , economics

Methylene‐bridged analogs of rimonabant were synthesized and evaluated for their activity on CB1 receptors. The pyrazine derivative showed some activity as a CB1 antagonist. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)

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