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Synthesis and Biological Evaluation of Methylene‐Bridged Analogs of the Potent Cannabinoid Receptor Antagonist Rimonabant
Author(s) -
Ślusarczyk Magdalena,
De Borggraeve Wim M.,
Hoornaert Georges,
Deroose Frederik,
Linders Joannes T. M.
Publication year - 2008
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200700960
Subject(s) - rimonabant , chemistry , cannabinoid receptor , methylene , antagonist , cannabinoid , pyrazine , cannabinoid receptor antagonist , derivative (finance) , stereochemistry , receptor , pharmacology , medicinal chemistry , biochemistry , medicine , financial economics , economics
Methylene‐bridged analogs of rimonabant were synthesized and evaluated for their activity on CB1 receptors. The pyrazine derivative showed some activity as a CB1 antagonist. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)