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Recent Approaches in the Synthesis of Conformationally Restricted Nucleoside Analogues
Author(s) -
Mathé Christophe,
Périgaud Christian
Publication year - 2008
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200700946
Subject(s) - chemistry , nucleoside , moiety , stereochemistry , nucleoside analogue , combinatorial chemistry
This review describes some approaches in the synthesis of conformationally restricted nucleoside analogues. The focus is on the preparation of nucleosides as monomers modified only on the pentofurano sugar moiety, with an additional linkage capable of modulating the dynamic conformational equilibrium of natural nucleosides. The results of the different structural modifications in terms of pseudorotational analysis, as well as the potential use of such conformationally restricted nucleoside analogues, are briefly presented.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)