Iron–Palladium Association in the Preparation of Indoles and One‐Pot Synthesis of Bis(indolyl)methanes | Zendy

Terrasson Vincent | Zendy; Michaux Julien | Zendy; Gaucher Anne | Zendy; Wehbe Johny | Zendy; Marque Sylvain | Zendy; Prim Damien | Zendy; Campagne JeanMarc | Zendy

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Iron–Palladium Association in the Preparation of Indoles and One‐Pot Synthesis of Bis(indolyl)methanes

Author(s) -

Terrasson Vincent,

Michaux Julien,

Gaucher Anne,

Wehbe Johny,

Marque Sylvain,

Prim Damien,

Campagne JeanMarc

Publication year - 2007

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.200700831

Subject(s) - annulation , chemistry , palladium , catalysis , alkylation , friedel–crafts reaction , lewis acids and bases , transition metal , organic chemistry , medicinal chemistry

Indoles were prepared by annulation of the parent alkynylanilines with the use of a new FeCl 3 –PdCl 2 catalytic combination. High yields were obtained by using low loadings of the transition‐metal complex (FeCl 3 –PdCl 2 : 2 and 1 mol‐%, respectively). One‐pot accesses to bis(indolyl)methanes and trisubstituted indoles through annulation/Friedel–Crafts alkylation and annulation/1,4‐Michael addition sequences, in which FeCl 3 acts both as a cooxidant and a Lewis acid are described.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)

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