Premium
Versatile One‐Pot Synthesis of 3‐Alkenylcoumarins
Author(s) -
Königs Pia,
Neumann Olivia,
Hackelöer Kristina,
Kataeva Olga,
Waldvogel Siegfried R.
Publication year - 2008
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200700819
Subject(s) - chemistry , phenols , molecule , carboxylic acid , organic chemistry , combinatorial chemistry , stereochemistry
A variety of 2‐acyl‐, 2‐aroyl‐ and 2‐formyl‐substituted phenols are converted in a one‐pot reaction with α,β‐unsaturated carboxylic acid chlorides into the corresponding 3‐alkenylcoumarins. Especially the labile 3‐vinylcoumarins are readily available by the simple to perform protocol. If longer alkenyl chains are involved in position 3, small molecules with excellent organo gelating properties are established. The mode of action for such aggregates is confirmed by X‐ray analysis of an analogue.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)