One‐Pot Synthesis of Functionalized 3‐(Trifluoromethyl)phenols by [3+3] Cyclization of 1,3‐Bis(silyl enol ethers) with α,β‐Unsaturated Trifluoromethyl Ketones | Zendy

Mamat Constantin | Zendy; Pundt Thomas | Zendy; Tam Dang T. H. | Zendy; Klassen Renske | Zendy; Reinke Helmut | Zendy; Köckerling Martin | Zendy; Langer Peter | Zendy

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One‐Pot Synthesis of Functionalized 3‐(Trifluoromethyl)phenols by [3+3] Cyclization of 1,3‐Bis(silyl enol ethers) with α,β‐Unsaturated Trifluoromethyl Ketones

Author(s) -

Mamat Constantin,

Pundt Thomas,

Tam Dang T. H.,

Klassen Renske,

Reinke Helmut,

Köckerling Martin,

Langer Peter

Publication year - 2008

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.200700801

Subject(s) - chemistry , silylation , trifluoromethyl , enol , phenols , domino , organic chemistry , pyran , enol ether , medicinal chemistry , catalysis , alkyl

Functionalized 3‐(trifluoromethyl)phenols were prepared by formal [3+3] cyclization of 1,3‐bis(silyl enol ethers) with readily available open‐chained and cyclic α,β‐unsaturated trifluoromethyl ketones. The reaction of 3,4‐dihydro‐5‐(trifluoroacetyl)‐2 H ‐pyran with 1,3‐bis(silyl enol ethers) resulted in a domino process to give new functionalized dihydropyrans. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)

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