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The Use of Solid‐Phase Synthesis Techniques for the Preparation of Peptide–Metal Complex Conjugates
Author(s) -
Dirscherl Georg,
König Burkhard
Publication year - 2008
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200700787
Subject(s) - chemistry , conjugate , solid phase synthesis , peptide synthesis , combinatorial chemistry , peptide , metal , phase (matter) , ligand (biochemistry) , amino acid , organic chemistry , biochemistry , receptor , mathematical analysis , mathematics
This microreview summarizes recent reports on the preparation of metal complex peptide conjugates by solid‐phase synthesis methods. Procedures for such conjugates are in many cases different from standard solid‐phase peptide synthesis protocols. Specific advantages of general strategies, the synthesis of peptide–ligand conjugates and complexation with excess metal ions on solid support or the incorporation of previously prepared metal complex amino acid derivatives are discussed.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)