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Synthesis of Pyrrolidine‐Based Imino Sugars as Glycosidase Inhibitors
Author(s) -
Doddi Venkata Ramana,
Vankar Yashwant D.
Publication year - 2007
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200700719
Subject(s) - pyrrolidine , chemistry , glycoside hydrolase , amination , ring closing metathesis , reductive amination , metathesis , ring (chemistry) , stereochemistry , iminosugar , organic chemistry , combinatorial chemistry , enzyme , catalysis , polymerization , polymer
Two pyrrolidine‐based imino sugars have been synthesized in an efficient manner, using regiospecific amination, ring closing metathesis, and diastereospecific dihydroxylations as key steps. These azasugars are found to be moderate inhibitors of glycosidases. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)