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Mild Electrochemical Deprotection of N ‐Phenylsulfonyl N ‐Substituted Amines Derived from ( R )‐Phenylglycinol
Author(s) -
Coeffard Vincent,
ThobieGautier Christine,
Beaudet Isabelle,
Le Grognec Erwan,
Quintard JeanPaul
Publication year - 2008
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200700709
Subject(s) - chemistry , electrochemistry , chemical reduction , cathodic protection , medicinal chemistry , scope (computer science) , combinatorial chemistry , organic chemistry , electrode , computer science , programming language
The electrochemical reduction of N ‐phenylsulfonyl N ‐substituted amines in a protic medium under constant cathodic potential was found to be a mild desulfonylation method, which is able to challenge the chemical ones. The influence of the nature of the N ‐substituents was considered in order to clarify the mechanistic aspects and to evaluate the scope of the method.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)