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Synthesis of Optically Active (+)‐Canangone, Its 6‐Epimer, and Determination of Absolute Configuration
Author(s) -
Koripelly Girish,
Saak Wolfgang,
Christoffers Jens
Publication year - 2007
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200700691
Subject(s) - chemistry , absolute configuration , epimer , optically active , annulation , natural product , stereochemistry , absolute (philosophy) , total synthesis , organic chemistry , catalysis , philosophy , epistemology
The first synthesis of canangone and its 6‐epimer is reported. The products are obtained in optically active form by an asymmetric Robinson annulation. The relative and absolute configuration of the natural product is established for the first time. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)