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Highly Efficient Direct Alkylation of Activated Methylene by Cycloalkanes
Author(s) -
Zhang Yuhua,
Li ChaoJun
Publication year - 2007
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200700686
Subject(s) - chemistry , alkylation , methylene , ketone , organic chemistry , catalysis , medicinal chemistry
A simple FeCl 2 ‐catalyzed C–C bond formation by direct alkylation of activated methylene by using simple cycloalkanes was developed. Several kinds of alkanes were found to react with phenyl β‐ketone ester and diketone compounds to afford alkylated 1,3‐dicarbonyl compounds in 10–88 % yields. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)