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Synthesis of Benzoazocines from Substituted Tetrahydroisoquinolines and Activated Alkynes in a Tetrahydropyridine Ring Expansion
Author(s) -
Voskressensky Leonid G.,
Listratova Anna V.,
Borisova Tatia.,
Alexandrov Grigoriy G.,
Varlamov Alexey V.
Publication year - 2007
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200700602
Subject(s) - chemistry , piperidine , ring (chemistry) , acetonitrile , methanol , tandem , medicinal chemistry , stereochemistry , organic chemistry , materials science , composite material
Tetrahydroisoquinolines underwent tandem piperidine ring enlargement in the presence of activated alkynes in acetonitrile or methanol, producing tetrahydrobenzo[ d ]azocines in high yields. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)