A Straightforward Synthesis of Isoxazoline‐Based Carbocyclic Nucleosides from 1,3‐Cyclohexadiene through Nitrosocarbonyl Chemistry | Zendy

Quadrelli Paolo | Zendy; Mella Mariella | Zendy; Carosso Serena | Zendy; Bovio Bruna | Zendy; Caramella Pierluigi | Zendy

Premium

A Straightforward Synthesis of Isoxazoline‐Based Carbocyclic Nucleosides from 1,3‐Cyclohexadiene through Nitrosocarbonyl Chemistry

Author(s) -

Quadrelli Paolo,

Mella Mariella,

Carosso Serena,

Bovio Bruna,

Caramella Pierluigi

Publication year - 2007

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.200700569

Subject(s) - chemistry , synthon , cycloaddition , benzonitrile , stereochemistry , purine , organic chemistry , combinatorial chemistry , catalysis , enzyme

3‐Benzoyl‐2‐oxa‐3‐azabicyclo[2.2.2]oct‐5‐ene undergoes cycloaddition with benzonitrile oxide to afford a mixture of syn and anti regioisomeric cycloadducts. The anti cycloadducts were easily elaborated to stereodefined isoxazoline‐based carbocyclic aminols that serve as synthons for the linear construction of purine nucleosides. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research