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The Creolophins: A Family of Linear Triquinanes from Creolophus cirrhatus (Basidiomycete)
Author(s) -
Opatz Till,
Kolshorn Heinz,
Birnbacher Judith,
Schüffler Anja,
Deininger Friederike,
Anke Timm
Publication year - 2007
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200700555
Subject(s) - chemistry , moiety , ketone , stereochemistry , ring (chemistry) , terpene , alcohol , organic chemistry
Complicatic acid and five novel linear triquinanes were isolated from mycelial cultures of Creolophus cirrhatus . The creolophins A, C, D, and E represent a novel type of highly oxidized triquinane sesquiterpenoids. Whereas those compounds with a secondary alcohol moiety in ring A are stable, the exomethylene ketone creolophin E ( 5 ) partly dimerized during workup to form the decacyclic 1,4‐dioxepin‐6‐one neocreolophin ( 6 ). Compounds 5 and 6 display cytotoxic activities against several tumor cell lines.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)