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Synthesis of Highly Functionalized Anthraquinones and Evaluation of Their Antitumor Activity
Author(s) -
Tietze Lutz F.,
Gericke Kersten M.,
Schuberth Ingrid
Publication year - 2007
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200700418
Subject(s) - chemistry , anthraquinones , in vitro , combinatorial chemistry , stereochemistry , side chain , organic chemistry , biochemistry , botany , biology , polymer
Highly functionalized anthraquinones which derive from the natural products mensacarcin, islandicin, and chrysophanol have been efficiently synthesized using a Diels–Alder reaction as key step. The introduction of the proposed pharmacophoric side chain unit has been achieved by an addition of an aryllithium species onto different aldehydes. Furthermore, the antitumor activity of these novel compounds has been studied by the in vitro growth inhibition of human lung carcinoma cells of line A549.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)