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Organoborane Reagents in the C ‐Alkylation of Aromatic Aldimines
Author(s) -
Valpuesta María,
Muñoz Carmen,
Díaz Amelia,
Suau Rafael,
Torres Gregorio
Publication year - 2007
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200700400
Subject(s) - aldimine , chemistry , reagent , imine , alkylation , aryl , borane , organic chemistry , medicinal chemistry , hydrogen peroxide , catalysis , alkyl
The reaction of an aldimine with dicyclohexylboron chloride in the presence of hydrogen peroxide gives N ‐[cyclohexyl(aryl)methyl]arylamines 2 in good yields via oxidized imine–borane complexes. The amines can also be obtained by a three‐component reaction involving an arenecarbaldehyde, an arylamine and a dialkylchloroborane reagent. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)