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Palladium‐Catalyzed C–N Bond Activation: The Synthesis of β‐Amino Acid Derivatives from Triethylamine and Acrylates
Author(s) -
Zou Bo,
Jiang HuanFeng,
Wang ZhaoYang
Publication year - 2007
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200700369
Subject(s) - triethylamine , chemistry , palladium , catalysis , acrylate , medicinal chemistry , polymer chemistry , organic chemistry , polymer , copolymer
In the palladium‐catalyzed reaction of acrylates, C–N bond activation and acetalization occurred under different conditions. Described herein is a highly efficient palladium‐catalyzed C–N bond activation reaction and subsequent new C–N bond formation to directly construct β‐amino acids from triethylamine and acrylate esters in isolated yields of up to 95 %.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)