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A Convenient and General Method for the Synthesis of Indole‐2,3‐dicarboxylates and 2‐Arylindole‐3‐carboxylates
Author(s) -
Sayyed Iliyas Ali,
Alex Karolin,
Tillack Annegret,
Schwarz Nicolle,
Michalik Dirk,
Beller Matthias
Publication year - 2007
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200700310
Subject(s) - chemistry , hydroamination , domino , indole test , acetylene , alkyl , organic chemistry , combinatorial chemistry , catalysis
A transition‐metal‐free, simple and efficient one‐pot method for the synthesis of indole‐2,3‐dicarboxylates and 2‐arylindole‐3‐carboxylates is described. The corresponding products are obtained by a domino hydroamination/Fischerindole cyclization in good‐to‐excellent yields from easily available 1‐alkyl‐1‐phenylhydrazines and acetylene carboxylates.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)