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Utilization of the Versatility of Sulfur in C–C Bond Formation and Cleavage: Synthesis of ABC Taxoid Skeletons
Author(s) -
Chavan Subhash P.,
Chavan Sambhaji P.,
Sonawane Harikisan R.,
Kalkote Uttam R.,
Sudrik Surendra G.,
Gonnade Rajesh G.,
Bhadbhade Mohan M.
Publication year - 2007
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200700301
Subject(s) - chemistry , taxoid , annulation , sulfur , cleavage (geology) , bond cleavage , ring (chemistry) , fragmentation (computing) , stereochemistry , combinatorial chemistry , organic chemistry , catalysis , medicine , surgery , geotechnical engineering , chemotherapy , fracture (geology) , computer science , paclitaxel , operating system , engineering
A practical and convenient five‐step protocol is described to access the ABC ring system of Taxol by utilizing the versatility of the sulfur atom in its various oxidation states viz., condensation/Pummerer cyclization/coupling/annulation/fragmentation. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)