Efficient, Transition Metal Mediated, Sequential, Two‐ and Three‐Component Coupling Reactions for the Synthesis of Highly Substituted Five‐Membered Ring Carbocycles
Coia Nicolas,
Bouyssi Didier,
Balme Geneviève
Publication year2007
Publication title
european journal of organic chemistry
Resource typeJournals
Abstract A Cu‐catalysed method for the preparation of highly substituted methylenecyclopentanes, through a sequence involving a Michael addition of stabilized enolates to activated enynes followed by an intramolecular carbocupration reaction, is presented. This method was also successfully combined with a Pd‐mediated coupling reaction to perform a new three‐component reaction through a transmetallation pathway on the vinylcopper intermediate. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
Subject(s)catalysis , chemistry , combinatorial chemistry , component (thermodynamics) , computational chemistry , coupling (piping) , coupling reaction , engineering , mechanical engineering , medicinal chemistry , metal , organic chemistry , physics , ring (chemistry) , stereochemistry , thermodynamics , transition metal
SCImago Journal Rank0.825

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