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Design, Synthesis and Evaluation of Serine Protease Inhibitor Analogues
Author(s) -
Kamoune Laila,
De Borggraeve Wim M.,
Gielens Constant,
Voet Arnout,
Robeyns Koen,
De Maeyer Marc,
Van Meervelt Luc,
Compernolle Frans,
Hoornaert Georges
Publication year - 2007
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200700180
Subject(s) - chemistry , serine protease , serine , thrombin , protease inhibitor (pharmacology) , combinatorial chemistry , enzyme inhibitor , stereochemistry , biochemistry , protease , enzyme , platelet , medicine , family medicine , human immunodeficiency virus (hiv) , biology , antiretroviral therapy , viral load , immunology
Recent efforts in the field of thrombin inhibitor research have focused on the identification of pyrazinone‐containing compounds. In this manuscript we describe the synthesis of the new pyrazinones 12 – 36 . All the targets were fully characterised and screened for serine protease inhibition. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)