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Transition Metal‐Catalyzed Oxidative Carbonylation of Amines to Ureas
Author(s) -
Díaz Delmy J.,
Darko Ampofo K.,
McElweeWhite Lisa
Publication year - 2007
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200700148
Subject(s) - phosgene , chemistry , carbonylation , catalysis , transition metal , organic chemistry , urea , oxidizing agent , oxidative phosphorylation , combinatorial chemistry , carbon monoxide , biochemistry
The synthesis of ureas from amines has traditionally been accomplished with stoichiometric reactions of phosgene or its derivatives, which are associated with environmental and waste disposal issues. Because of the prevalence of urea moieties in molecules of interest for several applications, alternative catalytic routes for the oxidative conversion of amines to ureas using CO as the carbonyl source have been developed. This microreview discusses recent developments in transition metal‐catalyzed oxidative carbonylation of amines to ureas as an alternative to phosgene and its derivatives. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)