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Design of Brønsted Neutral Organic Bases and Superbases by Computational DFT Methods: Cyclic and Polycyclic Quinones and [3]Carbonylradialenes
Author(s) -
Despotović Ines,
Maksić Zvonimir B.,
Vianello Robert
Publication year - 2007
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200700132
Subject(s) - chemistry , proton affinity , protonation , aromatization , affinities , proton , computational chemistry , deprotonation , organic base , base (topology) , stereochemistry , organic chemistry , ion , mathematical analysis , physics , mathematics , quantum mechanics , catalysis
Abstract The gas‐phase proton affinities and basicities of a large number of extended polycyclic π systems possessing a carbonyl oxygen head serving as a basic proton scavenger are explored by using DFT at the B3LYP/6‐311+G(d,p)//B3LYP/6‐31+G(d) level of theory. Some of these neutral organicsuperbases exhibit proton affinities in the range of 264–284 kcal mol –1 . In constructing these systems it turned out that a =C(NMe 2 ) 2 fragment attached to a quinoid six‐membered ring enhanced the basicity to a considerable extent. There is abundant and convincing evidence that protonation triggers strong aromatization of the quinoid rings. Moreover, sequential quinoid rings undergo the aromatic domino effect upon protonation if linearly aligned. Triadic analysis has revealed that highly pronounced basicity in some studied systems is a result of the synergistic action of Koopmans' frozen neutral base ionization energy contribution and subsequent relaxation of the radical cation. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)