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Directed Branched‐Regioselective Hydroformylation of 2‐Substituted Allylic o ‐DPPB Esters
Author(s) -
Breit Bernhard,
Grünanger Christian U.,
Abillard Olivier
Publication year - 2007
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200700120
Subject(s) - hydroformylation , regioselectivity , chemistry , allylic rearrangement , alkene , catalysis , medicinal chemistry , organic chemistry , rhodium
Branched‐regioselective hydroformylation of allylic o ‐DPPB esters has been accomplished with mono‐ and disubstituted alkene functions in good to excellent yields and selectivities. Optimized reaction conditions allowed the reaction of even trisubstitued alkenic functions. These reactions occur as a result of a significant rate‐accelerating effect exerted by the catalyst‐directing o ‐DPPB group, as exemplified by highly position‐, regio‐, and diastereoselective hydroformylation of the geranyl and neryl o ‐DPPB esters.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)