Premium
Electrons as a Reagent in Solid‐Phase Organic Synthesis
Author(s) -
Mentel Matthias,
Breinbauer Rolf
Publication year - 2007
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200700081
Subject(s) - chemistry , organic synthesis , reagent , context (archaeology) , combinatorial chemistry , catalysis , phase (matter) , electron transfer , organic reaction , organic molecules , covalent bond , substrate (aquarium) , solid phase synthesis , nanotechnology , molecule , organic chemistry , materials science , peptide , paleontology , biochemistry , oceanography , biology , geology
Solid‐Phase Organic Synthesis (SPOS) has become an important tool for the high‐throughput synthesis of bioactive molecules or new catalysts. The main advantage of this approach is the covalent attachment of the substrate to an insoluble support, enabling reaction workup through simple filtration. However, the heterogeneous nature of SPOS imposes limitations on the organic reactions applicable on solid phase. Electron‐transfer reactions and electroorganic synthesis are reaction types that have not yet received much attention in this context. In this review the current status of electron‐transfer reactions carried out on solid phase is described and future developments are discussed. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)