Fluorous “Racemic” Mixture Synthesis: Simultaneous Strategy for Demixing and Enantioseparation of Racemic Fluorous‐Tagged Products | Zendy

Tonoi Takayuki | Zendy; Mikami Koichi | Zendy

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Fluorous “Racemic” Mixture Synthesis: Simultaneous Strategy for Demixing and Enantioseparation of Racemic Fluorous‐Tagged Products

Author(s) -

Tonoi Takayuki,

Mikami Koichi

Publication year - 2007

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.200700037

Subject(s) - chemistry , enantiomer , organic chemistry , racemic mixture , combinatorial chemistry

Reported herein is the concept of fluorous “racemic” mixture synthesis (FRMS), which is applied to two types of proof‐of‐concept experiments. Mixtures of racemic O ‐benzoylmandelate derivatives and prochiral crotonamide derivatives, respectively, bearing different lengths of fluorous‐cleavable tags are taken through a segmented reaction sequence to provide their enantiomers, as well as their individual derivatives, by virtue of chiral β‐cyclodextrin columns. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)

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