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Cover Picture: Synthesis and Characterization of PY2‐ and TPA‐Appended Diphenylglycoluril Receptors and Their Bis‐Cu I Complexes (Eur. J. Org. Chem. 10/2006)
Author(s) -
Sprakel Vera S. I.,
Elemans Johannes A. A. W.,
Feiters Martin C.,
Lucchese Baldo,
Karlin Kenneth D.,
Nolte Roeland J. M.
Publication year - 2006
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200690020
Subject(s) - chemistry , catechol , copper , stereochemistry , ligand (biochemistry) , catechol oxidase , combinatorial chemistry , enzyme , receptor , organic chemistry , peroxidase , polyphenol oxidase , biochemistry
The cover picture shows the superposition of a synthetic model of the dinuclear copper enzyme catechol oxidase over the surface and active site of this enzyme. The model is the bis‐Cu I complex of a ligand‐appended diphenylglycoluril basket. This combines a reactive dinuclear copper site (the Cu I ions held by the ligands) for the binding and activation of molecular oxygen with a binding site (the diphenylglycoluril clip) for aromatic substrates to be oxidized. Details on this are discussed in the article by M. C. Feiters et al. on p. 2281 ff.