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Novel Sorbicillin Derivatives with an Unprecedented Carbon Skeleton from the Sponge‐Derived Fungus Trichoderma Species
Author(s) -
Neumann Kerstin,
AbdelLateff Ahmed,
Wright Anthony D.,
Kehraus Stefan,
Krick Anja,
König Gabriele M.
Publication year - 2007
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200601092
Subject(s) - sponge , chemistry , polyketide , stereochemistry , ring (chemistry) , carbon skeleton , absolute configuration , computational chemistry , organic chemistry , botany , biosynthesis , biology , enzyme
Chemical investigation of the fungus Trichoderma sp., isolated from the Caribbean sponge Agelas dispar led to four novel sorbicillinoid polyketide derivatives ( 1 – 4 ) with an unprecedented tricyclic ring system. The structures of all compounds, including the absolute configuration, were determined by interpretation of their spectroscopic data (1D and 2D NMR, CD, MS, UV and IR), and molecular modeling calculations. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)