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Synthesis of Benzofulvenes by Palladium‐Catalyzed Cyclization of 1,2‐Dialkynylbenzenes
Author(s) -
Lee ChiaYing,
Wu MingJung
Publication year - 2007
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200601029
Subject(s) - chemistry , palladium , acetonitrile , catalysis , medicinal chemistry , organic chemistry , combinatorial chemistry
A palladium‐catalyzed cyclization of enediynes for the synthesis of benzofulvenes 2 in yields of 59–76 % was accomplished by treatment of dialkynylbenzenes 1 with 5 mol‐% of PdX 2 and 3 equiv. of CuX 2 in acetonitrile at 60 °C for 2 h. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
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