Rapid Sequencing of Split‐and‐Mix Peptide Receptor Libraries – Identification of Binding Partners for Val‐Val‐Ile‐Ala in Aqueous Solution | Zendy

Shepherd Jon | Zendy; Langley G. John | Zendy; Herniman Julie M. | Zendy; Kilburn Jeremy D. | Zendy

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Rapid Sequencing of Split‐and‐Mix Peptide Receptor Libraries – Identification of Binding Partners for Val‐Val‐Ile‐Ala in Aqueous Solution

Author(s) -

Shepherd Jon,

Langley G. John,

Herniman Julie M.,

Kilburn Jeremy D.

Publication year - 2007

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.200601004

Subject(s) - chemistry , tetrapeptide , tripeptide , peptide , stereochemistry , receptor , combinatorial chemistry , peptide synthesis , biochemistry

Split‐and‐mix peptide libraries have been encoded by capping cleavable, laddered sequences with p ‐bromobenzoic acid, allowing rapid analysis of the cleaved ladder fragments by mass spectrometry. The encoding methodology has been applied to the synthesis of libraries of peptide receptors and a library of tripeptides functionalised with a bicyclic guanidinium unit has been successfully screened to identify binding partners for Val‐Val‐Ile‐Ala, the C‐terminal tetrapeptide sequence of the amyloid‐β protein, Aβ(1–42). (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)

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