RuCl 2 (dmso) 4  Catalyzes the Solvent‐Free Indirect Friedländer Synthesis of Polysubstituted Quinolines from Alcohols | Zendy

Martínez Ricardo | Zendy; Ramón Diego J. | Zendy; Yus Miguel | Zendy

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RuCl 2 (dmso) 4 Catalyzes the Solvent‐Free Indirect Friedländer Synthesis of Polysubstituted Quinolines from Alcohols

Author(s) -

Martínez Ricardo,

Ramón Diego J.,

Yus Miguel

Publication year - 2007

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.200600945

Subject(s) - chemistry , annulation , catalysis , quinoline , solvent , organic chemistry , medicinal chemistry , combinatorial chemistry

The first synthesis of polysubstituted quinoline derivatives from aromatic or aliphatic alcohols with RuCl 2 (dmso) 4 as catalyst under solvent‐free conditions is described. The reaction involves the in situ oxidation of alcohols to the corresponding carbonyl compounds through a hydrogen‐transfer, followed by a Friedländer annulation process. The whole process is a mild, efficient, selective, and high‐yielding single‐step procedure. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)

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