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RuCl 2 (dmso) 4 Catalyzes the Solvent‐Free Indirect Friedländer Synthesis of Polysubstituted Quinolines from Alcohols
Author(s) -
Martínez Ricardo,
Ramón Diego J.,
Yus Miguel
Publication year - 2007
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200600945
Subject(s) - chemistry , annulation , catalysis , quinoline , solvent , organic chemistry , medicinal chemistry , combinatorial chemistry
The first synthesis of polysubstituted quinoline derivatives from aromatic or aliphatic alcohols with RuCl 2 (dmso) 4 as catalyst under solvent‐free conditions is described. The reaction involves the in situ oxidation of alcohols to the corresponding carbonyl compounds through a hydrogen‐transfer, followed by a Friedländer annulation process. The whole process is a mild, efficient, selective, and high‐yielding single‐step procedure. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)