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New Scalable Asymmetric Aminomethylation Reaction for the Synthesis of β 2 ‐Amino Acids
Author(s) -
Moumné Roba,
Denise Bernard,
Guitot Karine,
Rudler Henri,
Lavielle Solange,
Karoyan Philippe
Publication year - 2007
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200600926
Subject(s) - chemistry , ketene , iminium , electrophile , silylation , amino acid , peptidomimetic , mannich reaction , combinatorial chemistry , organic chemistry , catalysis , peptide , biochemistry
β‐Amino acids are useful tools in the design of peptidomimetics, and the development of new methods for their syntheses, particularly the synthesis of β 2 ‐amino acids, remains an important challenge. Here we report a new scalable route based on the aminomethylation of silyl ketene N,O‐acetals by Mannich‐type iminium electrophiles. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)