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Phenylphosphoric Acid as a New Additive to Inhibit Olefin Isomerisation in Ruthenium‐Catalysed Metathesis Reactions
Author(s) -
Gimeno Nélida,
Formentín Pilar,
Steinke Joachim H. G.,
Vilar Ramón
Publication year - 2007
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200600908
Subject(s) - chemistry , isomerization , metathesis , ruthenium , acyclic diene metathesis , ring opening metathesis polymerisation , salt metathesis reaction , ring closing metathesis , organic chemistry , thiourea , alkene , combinatorial chemistry , catalysis , polymerization , polymer
A systematic study of the ruthenium‐catalysed metathesis of alkenes containing hydrogen‐bonding substituents (namely urea and thiourea groups) is presented. Under standard metathesis conditions, several of the substrates under study undergo alkene isomerisation instead of the targeted metathesis. However, in the course of these investigations it has been established that this unwanted isomerisation process can be suppressed by addition of phenylphosphoric acid to the reaction mixture. Some other potential isomerisation inhibitors (e.g. benzoic acid and salts of phosphoric acid) have been studied and their performance compared to that of phenylphosphoric acid. To extend the scope of phenylphosphoric acid, we also studied the metathesis of 1,3‐diallylurea. Interestingly, not only did we observe the complete suppression of the isomerisation process, but also that it is possible to obtain instead of the ring‐closing metathesis (RCM) product,ADMET oligomers resulting from the cross‐metathesis of diallylurea at higher concentrations. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)