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Asymmetric Synthesis of Aliphatic 2‐Hydroxy Ketones by Enzymatic Carboligation of Aldehydes
Author(s) -
Domínguez de María Pablo,
Pohl Martina,
Gocke Dörte,
Gröger Harald,
Trauthwein Harald,
Stillger Thomas,
Walter Lydia,
Müller Michael
Publication year - 2007
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200600876
Subject(s) - chemistry , benzaldehyde , enzyme , organic chemistry , enantioselective synthesis , aldehyde , catalysis
Benzaldehyde lyase (BAL) and benzoylformate decarboxylase (BFD) catalyse the asymmetric ligation of aliphatic aldehydes to afford enantiomerically enriched 2‐hydroxy ketones. Carboligation of linear aldehydes with both enzymes results in high levels of conversion and in enantioselectivities of up to 80 % ee . In cases involving branched aliphatic aldehydes, BAL enables the carboligation of 3‐methylbutanal with a high level of conversion and an enantioselectivity of 89 % ee .(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)