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Novel Building Blocks: 1‐Aryl‐2‐chloro‐1‐ethoxyethenes – Preparations and Transformations
Author(s) -
Yoshimatsu Mitsuhiro,
Sakai Miho,
Moriura Eri
Publication year - 2007
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200600863
Subject(s) - chemistry , aryl , acetal , prodrug , combinatorial chemistry , simple (philosophy) , organic chemistry , biochemistry , alkyl , philosophy , epistemology
We described here a simple method for the preparation of 1‐aryl‐2‐chloro‐1‐ethoxyethenes 2a – u , which are prodrugs for Alzheimer's disease, by the reaction of dichloroacetaldehyde diethyl acetal with various aryl and alkenyllithium compounds in high yields. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
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