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Intermolecular Hydroacylation by Transition‐Metal Complexes
Author(s) -
Jun ChulHo,
Jo EunAe,
Park JungWoo
Publication year - 2007
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200600846
Subject(s) - hydroacylation , chemistry , decarbonylation , aldehyde , ketone , heteroatom , transition metal , aldimine , organic chemistry , catalysis , ring (chemistry)
In this review, transition‐metal‐catalyzed intermolecular hydroacylation, which is a direct synthetic protocol generating ketones from aldehydes and unsaturated hydrocarbons, will be discussed. In order to avoid decarbonylation, one of the major side‐reactions occurring in transition‐metal‐catalyzed hydroacylation, several important strategies have been developed: An aldehyde ligand bearing a coordinating heteroatom at an appropriate position, a chelation auxiliary, and a masked form of the aldehyde, such as an aldimine or allylamine. Hydroacylation or its variations can also be applied to the synthesis of cycloalkanones and an α,β‐unsaturated ketone or to the carbon–carbon triple bond cleavage of an alkyne.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)