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Asymmetric Synthesis of Antithrombotic Agents M58163 and M58169: Dynamic Kinetic Resolution in Amide Formation Catalyzed by La‐Linked BINOL Complex
Author(s) -
Saitoh Fumihiko,
Nishida Hidemitsu,
Mukaihira Takafumi,
Aikawa Kohsuke,
Mikami Koichi
Publication year - 2006
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200600838
Subject(s) - chemistry , kinetic resolution , antithrombotic , amide , enantioselective synthesis , catalysis , stereochemistry , combinatorial chemistry , polyamide , organic chemistry , medicine , cardiology
The first asymmetric syntheses of antithrombotic agents M58163 and M58169 are reported. Dynamic kinetic resolution is observed in the amide formation step. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)
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