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Synthesis of a 24‐Membered Cyclic Peptide‐Biphenyl Hybrid
Author(s) -
Montero Ana,
Albericio Fernando,
Royo Miriam,
Herradón Bernardo
Publication year - 2007
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200600833
Subject(s) - chemistry , biphenyl , peptide , cyclic peptide , solid phase synthesis , combinatorial chemistry , molecule , peptide synthesis , amino acid residue , stereochemistry , amino acid , phase (matter) , organic chemistry , peptide sequence , biochemistry , gene
The synthesis of a 24‐membered macrocyclic peptide‐biphenyl hybrid with four amino acid residues and two biphenyl fragments was performed by a combination of solid‐phase and solution methodologies. The acyclic precursor was prepared by a solid phase methodology whereas the final macrocyclization was carried out by diisopropylcarbodiimide (DIPCDI) and N ‐hydroxybenzotriazole (HOBt) in solution. The target molecule was a moderate inhibitor of μ‐calpain. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)