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Direct C–C Coupling of Ferrocenyllithium and Azaheterocycles by Nucleophilic Substitution of Hydrogen – Synthesis of Mono‐ and 1,1′‐Diazinylferrocenes
Author(s) -
Chupakhin Oleg N.,
Utepova Irina A.,
Kovalev Igor S.,
Rusinov Vladimir L.,
Starikova Zoya A.
Publication year - 2007
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200600821
Subject(s) - chemistry , ferrocene , nucleophilic substitution , nucleophile , coupling (piping) , hydrogen , substitution reaction , combinatorial chemistry , substitution (logic) , catalysis , stereochemistry , medicinal chemistry , organic chemistry , electrochemistry , mechanical engineering , electrode , computer science , programming language , engineering
A versatile synthetic protocol was proposed for the direct C–C coupling of a ferrocene fragment with various azaheterocycles in the absence of metal catalysts on the basis of nucleophilic substitution of hydrogen. Monosubstituted and disubstituted heteroannular azinyl derivatives of ferrocene were prepared in good yields. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)