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Palladium‐Catalyzed Carboetherification and Carboamination Reactions of γ‐Hydroxy‐ and γ‐Aminoalkenes for the Synthesis of Tetrahydrofurans and Pyrrolidines
Author(s) -
Wolfe John P.
Publication year - 2007
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200600767
Subject(s) - pyrrolidine , chemistry , catalysis , palladium , tetrahydrofuran , molecule , combinatorial chemistry , organic chemistry , solvent
Substituted tetrahydrofuran and pyrrolidine moieties are displayed in a wide range of interesting biologically active molecules. The Pd‐catalyzed carboetherification or carboamination of γ‐hydroxy and γ‐aminoalkenes is a powerful tool for the construction of these heterocycles, as it is convergent and can allow access to a variety of analogs from a single γ‐hydroxy‐ or γ‐aminoalkene starting material. This microreview describes the current state of this field. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)