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Investigating Direct Alkynylation at the Bridgehead of Bicyclic Cages Using Silver(I) Acetylides
Author(s) -
Pouwer Rebecca H.,
Harper Jason B.,
Vyakaranam Kamesh,
Michl Josef,
Williams Craig M.,
Jessen Carsten H.,
Bernhardt Paul V.
Publication year - 2007
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.200600701
Subject(s) - chemistry , bicyclic molecule , alkynylation , substrate (aquarium) , adamantane , carbon fibers , stereochemistry , combinatorial chemistry , organic chemistry , medicinal chemistry , catalysis , oceanography , materials science , composite number , composite material , geology
Silver(I) acetylides facilitate direct carbon–carbon bond formation at the bridgehead position of adamantane, and in some instances related systems such as carborate anions and bicyclo[2.2.2]octanes. Substrate constraints along with attempts to further understand the underlying mechanism are presented. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)